Searchable abstracts of presentations at key conferences in endocrinology

ea0050ep032 | Bone and Calcium | SFEBES2017

Systemic Mastocytosis: A Rare but Important Cause of Osteoporosis

Lim Chong , Leonard Jonathan , Abbara Ali , Forbes Pat , Cox Jeremy , Comninos Alexander

We present a case of a 56 year-old man diagnosed with systemic mastocytosis by the dermatologists on presentation with classical skin lesions, confirmatory bone marrow biopsy and a tryptase level 105 ug/L (NR 2-14). Further genetic testing confirmed KIT D816V mutation. DEXA bone densitometry at diagnosis revealed marked osteoporosis (Lumbar T score -3.7 (Z -3.5), Femoral Neck T score of -2.0 (Z -1.1). He had no history of low trauma fracture and no relev...

ea0086p185 | Bone and Calcium | SFEBES2022

Finding the Culprit: A Rare Case of Oncogenic Osteomalacia

Rahim Haaris , Halim Sandra , Mulla Kaenat , Avari Parizad , Freudenthal Bernard , Comninos Alexander , Cox Jeremy

Oncogenic ostemalacia is a rare paraneoplastic syndrome characterised by renal phosphate wasting secondary to secretion of FGF-23 from mesenchymal tumours. Localisation of the tumour is wanted, as resection can lead to complete clinical and biochemical cure. We present a case of a 57 year old woman with a background of Vitamin D deficiency and secondary hyperparathyroidism, who presented with severe generalised aches and pain, worst in her ribs and thighs, such that she could ...

ea0086p275 | Reproductive Endocrinology | SFEBES2022

Follicle Sizes That are Most Likely to Yield Oocytes During In Vitro Fertilisation (IVF) Treatment

Alhamwi Toulin , Abbara Ali , Hanassab Simon , Comninos Alexander , Kelsey Tom , Salim Rehan , Heinis Thomas , Dhillo Waljit

Background: Infertility affects 1 in 6 couples causing devastating psychological impact. In vitro fertilisation (IVF) treatment can aid couples to conceive, but personalisation of treatment is needed to optimise patient outcomes. Machine learning can aid in the analysis of large complex datasets such as those encountered during IVF treatment. One example is in determining the optimal follicle size on the day of trigger to maximise the number of oocytes collected. Both follicle...

ea0091wf3 | Workshop F: Disorders of the parathyroid glands, calcium metabolism and bone | SFEEU2023

Differentiating Primary Hyperparathyroidism from Familial Hypocalciuric Hypercalcaemia Can Be Difficult: A Misleading Urinary Calcium to Creatinine Clearance Ratio

G Mills Edouard , J Hadjiminas Dimitri , Abbara Ali , Behary Preeshila , Cox Jeremy , N Comninos Alexander

Case: We report a 79-year-old female who was referred to our Endocrine Bone Unit with osteoporosis, which was initially treated with Alendronate (but poorly tolerated due to dyspepsia) followed by annual Zoledronate infusions. Her bone history was significant for a proximal humeral fragility fracture 30-years previously. She was an ex-smoker, had limited dietary calcium intake, and had a brother with osteoporosis. DEXA demonstrated T scores at lumbar spine -1.8, total hip -2.0...

ea0091cb58 | Additional Cases | SFEEU2023

Hypercalcaemia in a young female patient

Tsoutsouki Jovanna , North Matthew , Tebbs Daniel , Tharakan Goerge , Behary Preeshila , Cox Jeremy , N Comninos Alexander

A 35 year old lady presented with a one week history of back pain, myalgia, fatigue, epigastric pain, and persistent vomiting. She reported a four week history of reduced appetite and 4 kg weight loss. She had recently recovered from an uncomplicated COVID-19 infection. Past medical history included a previous eating disorder (anorexia and bulimia), and subsequent chronic gastritis. Drug history included Omeprazole 20 mg daily, Laxido 2 sachets daily and antacids (Rennies 4-8 ...

ea0091cb63 | Additional Cases | SFEEU2023

A Young Woman with Symptomatic Primary Hyperparathyroidism and a Renal Stone

Khan Shaila , Palazzo Fausto , Haboosh Sara , Behary Presheela , Wernig Florian , Cox Jeremy , Comninos Alexander

A 27-year old Caucasian woman was referred to the Endocrine Bone Clinic after investigations for general malaise revealed hypercalaemia and elevated parathyroid hormone levels. She had no history of constipation, abdominal pain, bone pain, or other related symptoms. She had no history of renal stones or fractures and no change in weight. Her past medical history included asthma and she took a salbutamol inhaler as required. She had no family history of endocrine pathology. Gen...

ea0065p114 | Bone and calcium | SFEBES2019

Intermittent Hypercalcaemia in a Young Man

Almazrouei Raya , Cox Jeremy , Fraser William D , Tang Jonathan , Comninos Alexander N

A 33 year-old man was referred to the endocrine bone clinic following presentation with a 4 mm kidney stone and hypercalcaemia. Apart from mild fatigue, he had no other hypercalcaemic or concerning symptoms. He was not on any medications or supplements. He had a positive family history for kidney stones and reported that his grandmother had been noted to have hypercalcaemia in the past. There was significant consanguinity in his family. Examination was entirely normal while bl...

ea0048wf10 | Workshop F: Disorders of the parathyroid glands, calcium metabolism and bone | SFEEU2017

Severe hypercalcaemia and osteoporosis in a patient with primary hyperparathyroidism

Ramli Rozana , Robinson Stephen , Yee Michael , Palazzo Fausto , Cox Jeremy PD , Comninos Alexander N

A 60-year-old Caucasian lady was referred to the metabolic bone clinic for assessment of osteoporosis. Her risk factors for osteoporosis included gender, postmenopausal status, childhood immobility due to illness, previous severe vitamin D deficiency, COPD, as well as an extensive smoking and alcohol history. She had multiple previous fragility fractures involving her ribs and both radii. A DEXA scan revealed lumbar osteoporosis (T -4.0) and femoral osteopenia (T -2.0). Thorac...

ea0044p212 | Reproduction | SFEBES2016

Gonadotrophin secretion is a useful adjunct in the diagnosis of patients with hyperprolactinaemia

Clarke S , Abbara A , Nesbitt A , Ali S , Comninos AN , Hatfield E , Martin NM , Sam A , Meeran K , Dhillo W

Background: Hyperprolactinaemia accounts for 1 in 7 patients presenting with amenorrhoea. Recent data suggests that prolactin acts at the hypothalamus to reduce GnRH-pulsatility. Conditions in which GnRH-pulsatility is reduced, such as hypothalamic amenorrhoea, favour FSH over LH secretion from the pituitary gland. We examined gonadotrophin secretion in hyperprolactinaemic patients as a surrogate marker of GnRH-pulsatility.Methods: A retrospective analys...

ea0044p239 | Thyroid | SFEBES2016

Optimising the medical treatment of Graves’ Disease through developing a novel carbimazole dosing-algorithm

Brewster Rosalind , Abbara Ali , Clarke Sophie , Comninos Alexander , Peters Deborah , Sam Amir , Meeran Karim , Dhillo Waljit

Introduction: Graves’ disease is the commonest cause of hyperthyroidism accounting for 80% of all cases. The first line treatment for Graves’ disease in the UK is medical therapy, most frequently using a ‘dose-titration’ regimen. Currently, there is a lack of guidance to aid clinicians in carrying out optimal dose-titration of carbimazole, resulting in a risk of under- or over-treatment. Thus, we aimed to develop a carbimazole dosing-algorithm for the medic...